The regenerative medicine specialist shares what former players should know before considering treatment.
Dr. Steve Sampson
1. What do you see in athletes who played contact sports for years?
“These warrior athletes are much like the veterans and soldiers we have treated. Mentally, they are used to being strong, and when they are injured, they struggle with that identity.”
Dr. Sampson says former athletes may be reluctant to acknowledge pain, sometimes describing it as “discomfort.” Yet a history of ligament or meniscus injuries can increase the risk of arthritis later in life.
2. What results can a patient realistically expect?
“These treatments do not work immediately. It took years to develop the problem, and it will take weeks to months to improve it.”
Dr. Sampson emphasizes that results vary by diagnosis, patient and procedure. These treatments may improve pain and function, but they are not a cure and should not be expected to regenerate an entire damaged joint.
3. How can alumni spot clinics that overpromise?
“It is a bit of the Wild West.”
Be cautious of advertisements promising cartilage regeneration or guaranteed results. Ask about the physician’s training, experience, injection guidance, potential complications and the evidence supporting the specific treatment being recommended.
4. What role do exercise and overall health play?
“These cells are not magic pixie dust. You need to optimize the patient and select the right candidate.”
Dr. Sampson stresses the importance of addressing factors such as blood sugar, weight and muscle mass. He tells patients that every pound lost takes about four pounds of pressure off the knees. Even when treatment helps reduce pain, safe movement and exercise remain central to maintaining function.
5. What is one thing you wish every former player knew about their options?
“Your body is your temple and your investment. You get one body, and the decisions you make about taking care of it influence the rest of your life.”
His advice: ask questions, explore appropriate options with a qualified physician and make decisions with the long game in mind.
Read the full interview: Explore the science, treatment options, limitations and questions to ask before considering regenerative medicine at Playing the Long Game: The Retired Athlete’s Playbook for Regenerative Medicine.
Disclaimer: This interview is educational and is not medical advice. Results vary. Talk with your own doctor before any treatment.
Highlights from the November 2026 Newsletter:
- Playing the Long Game: The Retired Athlete’s Playbook for Regenerative Medicine
- Dr. Steve Sampson: 5 Questions About Regenerative Medicine
- Regenerative Medicine for Football Bodies: What Works, What Doesn’t, and How to Tell
- American Diabetes Month: What Every Alumnus Should Know
- Family Caregivers Month: Behind Every Player Is a Support Team
- JOIN THE HUDDLE: Free Newsletter Sign-Up
